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The Child is not an adult in miniature
In childhood the immune and nervous systems undergo a physiological maturation.
During this delicate growth stage, the biological mechanisms that control inflammation, which are coordinated by the immune system, are not perfectly developed yet.
The physiological immune fragility in childhood, also associated with specific nutritional deficiencies, can result into Infantile Dermatitis and Auto-inflammatory Syndromes, the last characterised by: periodic fever, pelvic or joint pain, conditions of variable severity typically distinguished by skin rash and recurrent pulmonary infection. These problems tend to resolve spontaneously as the child grows, but this is not a reason to underestimate them, because the immunity maturation goes in parallel with the correct development of the Nervous System.
The adequate intake of active ALIAmides, in subjects vulnerable to auto-inflammatory syndromes, is necessary to promote the optimal acquisition of the biological mechanisms which control the inflammation, while fully respecting the natural neuro-immune maturation.
The child epidermis and mucosa appear to be more sensitive to infections and irritating phenomena. In fact, the protective function of the muco-cutaneous barrier has not reached yet the maximal efficiency in case of pathogens, allergen, chemical-physical and traumatic agents.
The muco-cutaneous mast cell, physiologically fragile in pediatric age, becomes hyper-active due to noxious stimuli (also having mild entity) and release inflammatory substances (e.g. histamine) causing pain, pruritus and swelling. These conditions are frequent in course of infantile dermatitis, phimosis and synechiae.
The control of the muco-cutaneous mast cell reactivity, through the topical application of ALIAmides able to increase the endogenous levels of Palmitoylethanolamide (PEA), normalises the peripheral threshold of pain and pruritus at level of the inflamed tissues.